Intermittent Positive-pressure Ventilation, Respiratory Physiological Phenomena
Conditions
Keywords
non-invasive intermittent positive-pressure ventilation, work of breathing, Pulse transit time
Brief summary
The investigators hypothesized that increasing non intentional leaks could increase work of breathing and could lead to patient/non-invasive ventilation (NIV) asynchrony. The main objective is to compare ventilatory pattern (work of breathing, flow, pressure) under NIV with and without non-intentional leaks in 10 awakened healthy subjects and 10 awakened and asleep obese hypoventilation syndrome (OHS) patients. Methods: While the subjects will be under NIV, several levels of leaks will be simulated in a random order with an automatically opening valve. Breathing pattern (work of breathing,flow, pressure, thorax and abdominal movements) will be recorded by Polygraphy. Healthy subjects will be recorded only during awakened state. OHS patients will be recorded both during awake and sleep sates. Analysis: A repeated measures analysis of variance (ANOVA) will compare work of breathing according to the different levels of leaks.
Interventions
OTHERNon intentional leaks during non invasive ventilation
During NIV sessions (in awake state for both the 10 healthy and the 10 OHS subjects and during sleep only for the OHS subjects), the investigators will create several levels of non intentional leaks in a random order
Sponsors
AGIR à Dom
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* OHS patients, in stable stade, teated with nocturnal non invasive ventilation for at least three months. * Healthy subjects without known pathology
Exclusion criteria
* OHS patients: instable cardio-respiratory status and/or acute cardio-respiratory failure three month before the inclusion. Latex allergy, oesophageal varices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main outcome measure:Work of breathing assessed by measurement of oesophageal pressure according to the levels of non intentional leaks during non invasive ventilation | Oesophageal pressure will be assessed during all the duration of the study (2hours for the healthy subjects, overnight for the OHS patients) |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measure: Assessments of the pulse transit time (PTT) and measurement of the oral opening (JAWSENS-NOMICS)according to the levels of non intentional leaks during non invasive ventilation | PTT and oral opening will be assessed during all the duration of the study (2hours for the healthy subjects, overnight for the OHS patients) |
Countries
France
Outcome results
None listed