Trauma
Conditions
Keywords
Combat casualty care, Hextend, Colloid
Brief summary
This is a chart review of all trauma patients during the specified time period. The purpose of this study is to examine the effects of resuscitation with hextend after trauma, in the adult population. The authors hypothesize that when compared to patients resuscitated with standard of care, resuscitation with Hextend will result in a mortality difference.
Interventions
DRUGHextend
IV fluid resuscitation to restore euvolemia after traumatic injury and surgery.
Sponsors
University of Miami
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admission to the trauma center
Exclusion criteria
* Pregnant women, children, psychiatric patients and prisoners.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality | Overall inpatient mortality upon discharge from the hospital with a mean length of stay of 8 days. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Hextend Patients that received Hextend as part of their resuscitation fluid. | 805 |
| Standard of Care Patients that received standard of care but no Hextend as part of their resuscitation. | 909 |
| Total | 1,714 |
Baseline characteristics
| Characteristic | Hextend | Standard of Care | Total |
|---|---|---|---|
| Age, Continuous Mean Age | 39 years STANDARD_DEVIATION 17 | 41 years STANDARD_DEVIATION 18 | 40 years STANDARD_DEVIATION 18 |
| Sex: Female, Male Female | 152 Participants | 190 Participants | 342 Participants |
| Sex: Female, Male Male | 653 Participants | 719 Participants | 1372 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — |
| other Total, other adverse events | 0 / 0 | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 | 0 / 0 |
Outcome results
Primary
Mortality
Time frame: Overall inpatient mortality upon discharge from the hospital with a mean length of stay of 8 days.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Hextend | Mortality | 42 participants |
| Standard of Care | Mortality | 81 participants |