Overactive Bladder Syndrome
Conditions
Keywords
OAB, urine, osmolality, urge, fluid intake, PPIUS, urge score, bladder
Brief summary
The researchers want to investigate how fluid intake influences the symptoms of OAB. The researchers will recruit 45 patients with OAB and randomize them (blind) in 3 groups (low/normal/high fluid intake). Patients will follow this drink pattern for 2-5 days, while filling in an standard micturation diary for 2 days. This micturation diary is coupled to: collection of multiple urine samples, urine pH measurements, and a Perception of Intensity of Urgency Scale (PPIUS) scoring table. All this is collected by the patients themselves. Urine samples will be analysed for osmolality by the clinical chemistry department.
Interventions
DIETARY_SUPPLEMENTwater
drinking water / normal dietary fluids for oral intake
Sponsors
Radboud University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* OAB patients
Exclusion criteria
* benign prostatic hyperplasia * neurogenic detrusor overactivity * urine tract infection * anticholinergics * intravesical botulin toxin * cardiac failure * renal insufficiency * sacral neurostimulation * percutaneous neurostimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine osmolality | 2 days |
| PPIUS urge-score | 2 days |
Secondary
| Measure | Time frame |
|---|---|
| urine pH | 2 days |
| PPIUS urge score | 2 days |
Countries
Netherlands
Outcome results
None listed