Probiotics in the Management of Acute Rotavirus Diarrhea in Bolivian Children

Conditions

Diarrhea, Rotavirus Infection

Keywords

acute diarrhea, rotavirus, probiotic, children

Brief summary

The purpose of this study is to determine the effect of probiotics in rotavirus acute diarrhea in children. The investigators will compare the effect of two different probiotics products.

Detailed description

Acute diarrhea remains being the second most frequent infectious condition in children, producing a high number of admissions yearly. In children below one year of age, rotavirus represents the main etiologic agent, both in developed and developing countries. In Bolivia, acute diarrhea affects about 30% of the group below 5 years of age. Probiotics appear as one of the alternatives currently under discussion. Also, evidence available suggests that probiotics shorten the time of diarrhea and therefore the time of rotavirus excretion. In daily practice, we are often limited by the type and number of probiotics products locally available; moreover, information about combined products is scarce. With this in mind, in this study we compared the efficacy of two commercially available products.

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Probiotics in the treatment of acute rotavirus diarrhoea. A randomized, double-blind, controlled trial using two different probiotic preparations in Bolivian children.

Grandy G, Medina M, Soria R, Terán CG, Araya M.

2010-08-25117 citations

10.1186/1471-2334-10-253

Interventions

DRUGGB (Florestor)

S. Boulardii preparation of 1 gram twice daily for 5 days

DRUGGRALB

mixed probiotic preparation 1 gram twice daily for 5 days.

DRUGGC (placebo)

Placebo 1 gram twice daily for 5 days.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

1 Months to 23 Months

Healthy volunteers

No

Inclusion criteria

* Positive stool sample for rotavirus test

Exclusion criteria

* Severe malnourishment * Severe dehydration * Use of antibiotics, probiotics or nitazoxanide 2 weeks before admission * Systemic infections * Severe chronic disease * Mixed enteric infections besides rotavirus

Design outcomes

Primary

Measure	Time frame
Duration of diarrhea	within the first 72 hours during hospitalization

Secondary

Measure	Time frame
Duration of fever	the first 72 hours during hospitalization
Duration of vomiting	the first 72 hours during hospitalization
Duration of hospitalization	4 days

Countries

Bolivia

Outcome results

None listed