Cervix Cancer
Conditions
Keywords
Cervix Cancer, IMRT, Organ Motion, Target Definition
Brief summary
A theoretical planning study to compare the normal tissue irradiation when using intensity modulated radiotherapy (IMRT) as opposed to standard radiotherapy for the definitive treatment of cervical cancer.
Detailed description
Radiotherapy in combination with chemotherapy is the standard treatment of locally advanced cervix cancer, however with traditional techniques large volumes of bowel and bladder are irradiated causing short-term and long-term genito-urinary and gastro-intestinal side effects. IMRT has the potential to conform precisely to the target and spare normal tissues and reduce side effects. However because there are large dose gradients there is the potential to miss the target due to organ motion. Recent studies have documented organ motion and will be used to define the target. Approximately 60 planning scans, previously used to treat patients with cervix cancer, will be used to replan using an IMRT technique and differences in doses to tumour and normal tissues compared.
Interventions
RADIATIONIMRT planning
RADIATION4-Field Radiation Planning
Sponsors
Sunnybrook Health Sciences Centre
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* last 60 patients treated definitively for cervical cancer at Sunnybrook Odette Cancer Centre
Exclusion criteria
* no imaging and no anatomical description of disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in dose to organs at risk | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Target Coverage | 6 months |
Countries
Canada
Outcome results
None listed