Search for Biomarkers in Human Glaucoma: Lymphocytes Alterations and Rate of Progression

Search for Biomarkers in Human Glaucoma: Possible Correlations Between Alterations in Peripheral Lymphocytes and Disease Severity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00981422

Enrollment

Registered

2009-09-22

Start date

2007-06-30

Completion date

2008-06-30

Last updated

2009-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma, Open-Angle

Keywords

glaucoma, immunology, immunophenotype

Brief summary

The aim of this study was to evaluate the lymphocyte phenotype in primary open- angle glaucoma (POAG) patients compared to healthy subjects of the same age, in order to confirm the importance of immune responses in glaucoma and the possible correlation to the severity of the disease.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of primary open-angle glaucoma * age between 19 an 85 years old

Exclusion criteria

* age less than 19 or more than 85 yrs * positive history for (a) neurodegenerative diseases, (b) autoimmune diseases, (c) cancer, (d) viral infection and (e) diabetes, (f)systemic inflammation

Design outcomes

Primary

Measure	Time frame
compare the lymphocyte phenotype of POAG patients to healthy subjects of the same age	the same day of bloodwithdrawal

Secondary

Measure	Time frame
correlate the immunophenotype of POAG patients to the severity of disease	within 3 months after blood withdrawal

Countries

Italy

Outcome results