The Time of Positive Conversion of Interferon-γ Releasing Assay After Tuberculosis Exposure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00981071

Enrollment

Registered

2009-09-22

Start date

2009-05-31

Completion date

2010-04-30

Last updated

2010-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculosis

Keywords

Tuberculosis, QuantiFERON, Outbreak, Conversion

Brief summary

The aim is to evaluate the time of positive conversion after exposure to smear positive pulmonary tuberculosis (TB) in a platoon of Korean military, a closed communal setting.

Detailed description

In a platoon where TB outbreak occurred, we performed low dose chest CT (LDCT), QuantiFERON-TB gold in tube (QFT) and two-step (0, 4weeks) TST for outbreak investigation. We perform QFT at 0, 2, 4, 8 and 12 weeks after initial investigation for soldiers with negative QFT results, and soldiers with positive QFT and normal LDCT took isoniazid and rifampin for 3 months as treatment of latent TB.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Healthy volunteers

Yes

Inclusion criteria

* All soldiers who assigned to the military platoon where a tuberculosis outbreak occurred

Exclusion criteria

* Soldiers who could not complete study or refused the study protocol

Outcome results