Quantification of Respiratory-induced Prostate Motion

Pilot Study on the Quantification of Respiratory-induced Prostate Motion During Radiation Therapy Using Continuous Real-time Tracking

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00980993

Enrollment

Registered

2009-09-21

Start date

2012-09-30

Completion date

2014-09-30

Last updated

2019-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Keywords

Prostate, Motion, Respiration

Brief summary

Patient anatomy and position during the course of radiation therapy can vary from those used for treatment planning; a function of patient movement, uncertainty in positioning system, and organ motion. Traditionally, treatment margins are designed to compensate for interfraction prostate setup variability. This approach has the potential to lower the overall effectiveness of treatment because the prostate gland is a continuously moving target whose motion cannot be accurately accounted for solely on the basis of interfraction movement. More recently, the dosimetric relevance of intra-fraction prostate motion has been recognized, and may be compensated for by continuous real-time adaptive radiation therapy afforded by the Calypso 4D Localization System™. In the current study, the investigators propose to characterize intrafraction prostate motion. The investigators hypothesize that intrafraction prostate motion is correlated with respiratory motion.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Histologically confirmed stage I-III adenocarcinoma of the prostate gland * Age \> 18 years. Males of all races and ethnic groups * Scheduled to receive radiation for definitive therapy * Three (3) electromagnetic transponders implanted into prostate gland

Exclusion criteria

* Does not satisfy inclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Motion amplitude	Continuously during radiation administration (generally 8 to 15 minutes in duration)	Measured at frequency of 10Hz

Countries

United States

Outcome results