Use of Local Analgesia With Epinephrine During Total Hip Arthroplasty (THA)

Effect of the Injection of Local Analgesia With Epinephrine During Total Hip Arthroplasty on the Blood Losses Per and Operatively.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00980616

Enrollment

150

Registered

2009-09-21

Start date

2009-09-30

Completion date

2012-03-31

Last updated

2012-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthroplasty, Replacement, Hip

Keywords

Arthroplasty, hip, blood losses, pain, local analgesia, epinephrine, Primary total hip arthroplasty

Brief summary

The aim is to determine if the use of infiltration with an adrenalin solution in the operative field of Total Hip Arthroplasty (THA), allays a significant reduction of the cumulated volume of bleeding (pre and post operative) without increasing the per and post operative risks. At the same time, the effect on the post operational pains is evaluated.

Detailed description

This prospective randomized study compares a population receiving a local anaesthetic (ropivacaine, adrenalin and physiological serum) in the operative field to a population undergoing a standard protocol. The cumulated volume of bleeding per and post operative are recorded and complete blood count (CBC).

Interventions

DRUGropivacaine, physical serum and adrenalin

A: experimental group: 235 mg of ropivacaine, 5 ml physical serum and 0.5 mg of adrenalin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Primary total hip arthroplasty * Age between 50 and 85

Exclusion criteria

* fracture of the femoral neck * patients with contraindications for local anaesthesia

Design outcomes

Primary

Measure	Time frame
measuring volume of cumulated bleeding per and post operative and analyse of complete blood count (CBC)	pre and post operative

Secondary

Measure	Time frame
Womac score pre operative, at 3 months and at 12 months	at 3 months and 12 months
Visual analogue pain score (VAS) during hospitalisation	at 3 months and 12 months
Consumption of analgesics	at 3 months and 12 months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026