Microparticles in Pediatric Inflammatory Disease

Microparticles in Pediatric Inflammatory Bowel Disease

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00979485

Enrollment

Registered

2009-09-18

Start date

2009-08-31

Completion date

2011-05-31

Last updated

2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease, Ulcerative Colitis

Keywords

Pediatric IBD, Microparticles

Brief summary

The purpose of this study is to provide data correlating levels of microparticles that circulate in the blood and disease activity in children with inflammatory bowel disease (IBD). The hypothesis is that circulating microparticles will be higher in children with active IBD, show inflammatory activity, and will be low in patients in remission as well as in healthy controls.

Detailed description

Once the response of microparticles to inflammation is defined in this patient population, the microparticles can be used as biomarkers of disease activity and could potentially use microparticles as targets of therapeutic agents. This cross sectional study will enroll 15 Crohn's patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric Crohn's disease activity index), 15 Ulcerative Colitis patients (5 inactive, 5 mild, 5 moderate-severe disease based on the pediatric ulcerative colitis activity index), and 10 healthy controls.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

8 Years to 17 Years

Healthy volunteers

Yes

Inclusion criteria

* Children with IBD based on endoscopic, histologic, radiologic, or laboratory data * Ages between 8 and 17 years old

Exclusion criteria

* Anyone with a concurrent illness since infection can affect microparticle levels

Countries

United States

Outcome results