Genetic Examination of Patients With Primary Multiple Hernia

Genetic Differences Between Patients With Multiple Hernia and a Healthy Control Group

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00979095

Enrollment

Registered

2009-09-17

Start date

2009-06-30

Completion date

2011-12-31

Last updated

2010-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Hernia

Keywords

multiple hernia

Brief summary

The investigators are performing a genetic study of patients with multiple hernias (at least 3 primary hernias) versus a healthy control group. This genetic information is compared with circulating and subcutaneously biomarkers such as matrix-metalloproteinases (MMP's). The hypothesis is that patients with multiple hernias have different expression of specific genes compared to the healthy control group.

Detailed description

Other examinations performed on the patients enrolled in this study: * Ultrasound (US) examination of the abdominal aorta to discover possible abdominal aortic aneurysms. * Beightons score to evaluate the degree of joint hypermobility.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients with minimum 3 primary hernias

Exclusion criteria

* Patients under 18 years

Design outcomes

Primary

Measure	Time frame
Genetic expression of relevant genes between the groups	12 months

Secondary

Measure	Time frame
Amount of serological biomarkers (MMP's) correlated to gene expression	12 months

Countries

Denmark

Outcome results