Effects of Artificial Sweetener on Gastrointestinal (GI) Peptide Secretion

Carbohydrates and Non Caloric Sweeteners: Differential Effects on Appetite and Secretion of Gastrointestinal Satiety Peptide

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00978900

Enrollment

Registered

2009-09-17

Start date

2008-12-31

Completion date

2009-07-31

Last updated

2009-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

satiety peptides, GLP-1, PYY, ghrelin, appetite profile, Sweetening Agents

Brief summary

The purpose of this study is to examine the influence of artificial sweeteners (aspartame, acesulfame K, sucralose) and carbohydrate sugars (glucose, fructose) on the release of gastrointestinal satiety hormones in humans.

Detailed description

Artificial Sweeteners significantly lower energy density of foods and beverages. They are used by diabetics as sugar substitutes as well as by consumers as aids for dietary control. Despite numerous studies which show mainly no influence of artificial sweeteners on glucose metabolism and food intake, discrepancies consist about the real effects of artificial sweeteners. Studies by Blundell and Hill in 1986 have however shown that the consumption of artificial sweeteners resulted in an increase of appetite ratings; the efficiency of AS has therefore been questioned. With respect to the world wide increase in the prevalence in obesity, it seems important to clarify whether artificial sweeteners can help regulate body weight or not. This study will explore the effect of artificial sweeteners on the release of the gastrointestinal satiety hormones PYY, GLP-1, GIP and ghrelin.

Interventions

DIETARY_SUPPLEMENTArtificial sweeteners; Carbohydrate Sugars

sweetening agent dissolved in tap water, administered via intragastric tube

DIETARY_SUPPLEMENTWater

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy subject with a body-mass index of 19.0-24.5 * Normal eating habits * Age 18-40 years * Stable body weight for at least three months

Exclusion criteria

* Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * history of gastrointestinal disorders * food allergies

Design outcomes

Primary

Measure	Time frame
Gastrointestinal peptide secretion	2 hour blood sampling

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026