Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

Sirtuin Mediated Effects of 36 h Fast and 1 h Exercise

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00978640

Enrollment

Registered

2009-09-17

Start date

2009-09-30

Completion date

2012-06-30

Last updated

2012-06-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Sirt1 activity

Brief summary

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1). Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max. In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Interventions

OTHERfast and exercise

fasting 36 h and exercise 1 h 50% VO2max

OTHERexercise

exercise 1 h 50% VO2max

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy men * Body mass index (BMI) 20-26 * age 18-45 years

Exclusion criteria

* any kind of disease * any use of medicine

Design outcomes

Primary

Measure	Time frame
Sirt1 activity	60 min

Secondary

Measure	Time frame
secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.	4 h

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026