Microenvironment of Adipose Tissue in Endocannabinoid System

Microenvironment of Adipose Tissue in Endocannabinoid System Before and After Roux-en-y Gastric Bypass Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00978289

Enrollment

Registered

2009-09-16

Start date

2008-07-31

Completion date

2012-12-31

Last updated

2013-06-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

obesity, gastric bypass surgery

Brief summary

The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* BMI\>35 kg/m2 * Age 20-60 yrs * Approved and scheduled for gastric bypass surgery * Stable body weight for past 3 months

Exclusion criteria

* Positive pregnancy test * Previous gastric surgeries * Intercurrent infections * History of ketoacidosis or current metabolic acidosis * Serum creatinine or liver function tests \> 2 times upper limits of normal * Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.

Countries

United States

Outcome results