Infertility
Conditions
Keywords
infertility, ICSI, hCG, infertility treatment
Brief summary
The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. The study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone antagonist protocol for in vitro fertilization, are studied. In addition to the histological findings, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, the investigators want to study the implantation potential.
Interventions
200 IU per day in the late follicular phase
Sponsors
Universitair Ziekenhuis Brussel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* \< 36 years on day of randomisation * FSH \< 12 in the early follicular phase * Normal ultrasound scan * BMI between 18 and 29 (both inclusive) * Randomisation at outpatient clinic
Exclusion criteria
* Endometriosis ≥ grade 3 * PCO syndrome * Poor responder * Endocrine or metabolic abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| number of oocytes | 2 weeks after start of the treatment |
Countries
Belgium
Outcome results
None listed