Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study

Effects of Long-term Therapy With LDL-lowering Plus HDL Raising on Carotid Intima-media Thickness (CIMT) - Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00976014

Acronym

FATS

Enrollment

Registered

2009-09-14

Start date

2006-12-26

Completion date

2012-05-09

Last updated

2021-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Stenosis

Brief summary

This observational study looks at Carotid Stenosis in two groups of subjects using a non-invasive procedure, B-mode ultrasound. One group of subjects has had long-term intensive lipid altering therapy (lowering LDL-C plus raising HDL-C). The second group of patients has been on conventional standard of care treatment for carotid stenosis. The study will look at the Carotid Intima-media Thickness (CMIT) in both groups. Hypothesis: CIMT will differ between the two groups, such that the CIMT will be less in the subjects on intensive lipid altering therapy.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Healthy volunteers

Inclusion criteria

* Intensive Lipid-lowering Therapy Group: Subjects currently enrolled in the Familial Atherosclerosis Treatment Observational Study. * Usual Care Group: Subjects who were in the FATS OS Study in the past, but have since quit the study and opted for conventional standard of treatment.

Exclusion criteria

* No past or present participation in the FATS OS Study.

Design outcomes

Primary

Measure	Time frame
Carotid Intima-media Thickness	Up to 3 years

Countries

United States

Outcome results