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Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates

The Effect of Caffeine or Protein Co-ingestion With Carbohydrate on Post-exercise Muscle Glycogen Synthesis Rate.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00975390
Enrollment
14
Registered
2009-09-11
Start date
2009-02-28
Completion date
2009-09-30
Last updated
2015-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Recovery

Keywords

Glycogen, Carbohydrate, Protein, Caffeine, Post exercise muscle glycogen synthesis, Sports nutrition

Brief summary

The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes. The investigators hypothesize that both interventions (the addition of caffeine or protein+leucine) will lead to higher glycogen re-synthesis compared to the ingestion of CHO only, and that the co-ingestion of protein and leucine will result in the highest muscle glycogen synthesis rates.

Interventions

DIETARY_SUPPLEMENTCarbohydrate

1.2 g/kg/h

DIETARY_SUPPLEMENTCarbohydrate and protein ingestion

1.2 g/kg/h carbohydrate plus 0.4 g/kg/h protein

DIETARY_SUPPLEMENTCarbohydrate and caffeine ingestion

1.2 g/kg/h carbohydrate and 1.67 g/kg/h caffeine

Sponsors

Maastricht University Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* male cyclists * healthy * BMI \< 25

Exclusion criteria

* female * use of medication * non cycling * BMI \> 25

Design outcomes

Primary

MeasureTime frame
Muscle glycogen synthesis rates6 hours

Secondary

MeasureTime frame
Glycogen synthase activity, plasma glucose, insulin, free fatty acids and epinephrine responses6 hours

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026