Levobupivacaine on Heart Rate Variability (HRV) in Spinal Anesthesia

Comparison of the Effects of Levobupivacaine and Bupivacaine on Heart Rate Variability in Spinal Anesthesia

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00974961

Acronym

HRV

Enrollment

Registered

2009-09-11

Start date

2009-09-30

Completion date

2010-07-31

Last updated

2010-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia

Keywords

Levobupivacaine, HRV, Spinal Anesthesia, Responses of ANS to these two drugs

Brief summary

The purpose of this study is to compare if the effect of levobupivacaine on autonomic nervous system smaller than that of bupivacaine.

Detailed description

Obtain the heart rate variability (in means and standard deviation, including the high frequency, low frequency and its ratio) data of before and after spinal anesthesia with ECG (and Heart Rate Variability Analyzer) in 2 groups. Meanwhile, record the blood pressure on each subject.

Interventions

DRUGbupivacaine, levobupivacaine

intrathecal injection 15\ 20mg(for Levobupivacaine) or 10\ 15mg(for Bupivacaine) once

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Indicated for spinal anesthesia

Exclusion criteria

* Allergic reaction to local anesthetics * Coagulopathy * Severe spinal deformity * Cardiac diseases * Metabolic diseases (such as DM, thyroid or adrenal diseases)

Design outcomes

Primary

Measure	Time frame
HRV values	5 minutes after drug administration

Countries

Taiwan

Contacts

Primary ContactShih-Yu Chen, M.D.

hitantc@gmail.com886-5-5323911

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026