Cesarean Section
Conditions
Keywords
Spinal anesthesia, Fluid therapy
Brief summary
Fluid management plays an essential role in cesarean section. In previous study (NCT00488111) the investigators found that prior-epidural anesthesia fluid management produced a more significant role in stabilizing the blood pressure and better prognosis after cesarean delivery than that of the posterior-anesthesia ones. Given epidural anesthesia has a time interval before reaching the best state of anesthesia, so the fluid management also has a relatively adequate time to resuscitation. In reality, spinal anesthesia is used popularly except for the epidural anesthesia, whereas spinal anesthesia would produce more significant fluctuation of the hemodynamics compared with the latter. Herein the investigators proposed whether the prior-spinal anesthesia fluid management also produced similar effect on hemodynamic characteristics to the epidural anesthesia.
Interventions
DRUGRinger's Lactate
Ringer's Lactate 8 ml/kg was given intravenously before or after spinal anesthesia in cesarean section
Hydroxyethyl starch (6%) was given before or after spinal anesthesia in cesarean section
Sponsors
Nanjing Maternity and Child Health Care Hospital
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* 21-40 yr * First time of delivery * ASA status I-II * No premature * No genetic and infectious diseases * Chinese
Exclusion criteria
* \< 21 yr * \> 40 yr * Subjects with cardiac and pulmonary disorders * Dislocation of placenta * Pregnant hypertension * Allergy to local anesthetics * Unwilling to cooperation * Need intraoperative administration of vascular active agents * With significant delivery side effects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of ephedrine and phenylephrine | Anesthesia begin (0 min) to 120 min after anesthesia |
| Total volume of colloid or crystalloid | Fifteen minutes before anesthesia to 120 min after anesthesia |
| One-min and 5-min Apgar scores | The first and fifth minute after cesarean successful delivery |
| Recurrence of hypotension after ephedrine or phenylephrine | Anesthesia begin (0 min) to 120 min after anesthesia |
| Duration of hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
| Low umbilical cord pH (artery < 7.20) | At the time of successful delivery (0 min) |
| Oxygen saturation during hypotension | Anesthesia begin (0 min) to 120 min after anesthesia |
Countries
China
Outcome results
None listed