Asthma
Conditions
Keywords
pediatric, dexamethasone, management, corticosteroids, asthma
Brief summary
The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.
Interventions
DRUGOra Sweet
A pharmaceutical suspending vehicle and flavouring agent added to the dexamethasone. All arms received the same amount of dexamethasone based on the child's weight, only in different volumes.
DRUGDexamethasone
Sponsors
IWK Foundation
IWK Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
2 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* acute asthma exacerbation * requiring oral systemic corticosteroids for management
Exclusion criteria
* preference for pills over liquid formulation * history of Nissen fundoplication surgery * needed immediate airway intervention * require oral medications to be given via a G or J tube * if patient care would be compromised * enrolled in the study on a previous visit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study was to assess whether smaller volumes of oral dexamethasone resulted in better tolerability, specifically less vomiting, in pediatric patients with an acute exacerbation of asthma. | During Emergency Department visit |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate asthma symptom control post emergency room visit for acute asthma exacerbation. | 7-14 days following emergency dept visit |
Countries
Canada
Outcome results
None listed