Respiratory Tract Infections
Conditions
Keywords
vitamin D, infection, Vitamin D for the prevention of respiratory tract infections
Brief summary
The investigators earlier clinical study in 754 young Finnish men demonstrated a significant negative association of serum 25-OHD concentration with acute respiratory tract infections. The present study aimed to determine whether vitamin D supplementation may decrease the incidence of acute respiratory tract infections.
Detailed description
Subjects comprised 164 male conscripts at a military base in Finland. Half of the participants were randomly allocated to receive 400 IU vitamin D daily and half received placebo from October through March. Serum vitamin D and plasma parathyroid hormone concentrations were determined. Subjects were followed for 6 months and the primary outcome was the number of days absent from duty due to ARTI.
Interventions
DIETARY_SUPPLEMENTvitamin D
vitamin D3 400 IU daily
DIETARY_SUPPLEMENTplacebo
placebo
Sponsors
Finnish Defense Forces
Tampere University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Healthy volunteers
Yes
Exclusion criteria
* Use vitamin D
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days absent from duty due to respiratory tract infection | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of men remaining healthy throughout the 6-month study period | 6 months |
| The number needed to treat calculated from the proportion of men without any days absent from duty | 6 months |
Countries
Finland
Outcome results
None listed