Lymphoma
Conditions
Keywords
stage I adult diffuse large cell lymphoma, contiguous stage II adult diffuse large cell lymphoma, noncontiguous stage II adult diffuse large cell lymphoma, stage III adult diffuse large cell lymphoma, stage IV adult diffuse large cell lymphoma
Brief summary
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, cyclophosphamide, vincristine sulfate, and prednisolone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving more than one drug (combination chemotherapy) together with rituximab may kill more cancer cells. PURPOSE: This phase II trial is studying giving gemcitabine hydrochloride, cyclophosphamide, vincristine sulfate, and prednisolone together with rituximab to see how well it works in treating patients with newly diagnosed diffuse large B-cell lymphoma.
Detailed description
OBJECTIVES: * To determine whether rituximab, in combination with non-cardiotoxic chemotherapy comprising gemcitabine hydrochloride, cyclophosphamide, vincristine sulfate, and prednisolone, is efficacious in a group of patients who are unfit for CHOP chemotherapy. OUTLINE: This is a multicenter study. Patients receive gemcitabine hydrochloride IV over 30 minutes on days 1 and 8; cyclophosphamide IV, vincristine sulfate IV, and rituximab IV on day 1; and oral prednisolone once daily on days 1-5. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed every 3 months for 1 year, every 4 months for 1 year, and then every 6 months for 1 year.
Interventions
BIOLOGICALrituximab
DRUGcyclophosphamide
DRUGgemcitabine hydrochloride
DRUGprednisolone
DRUGvincristine sulfate
Sponsors
University College, London
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed CD20-positive diffuse large B-cell non-Hodgkin lymphoma (DLBCL) according to the current WHO classification, including all morphological variants * Newly diagnosed disease * Bulky stage IA-IV disease * No non-bulky stage IA disease * Measurable disease * Not eligible for CHOP chemotherapy due to impaired cardiac function * Cardiac status that does not allow the administration of 8 courses of R-CHOP chemotherapy, as defined by 1 of the following criteria: * Ejection fraction less than 50% as assessed by either ECHO or MUGA scan * NYHA class III-IV * No high-grade transformation of low-grade lymphoma * No symptomatic central nervous system or meningeal involvement by the lymphoma * No AIDS-related lymphoma PATIENT CHARACTERISTICS: * ECOG performance status 0-3 * Life expectancy \> 3 months * Platelet count \> 100 x 10\^9/L * WBC \> 3 x 10\^9/L * Neutrophils \> 1.5 x 10\^9/L (unless elevated level attributed to bone marrow infiltration by lymphoma) * Serum bilirubin \< 50 μmol/L * Transaminases \< 2.5 times upper limit of normal (unless elevated level attributed to lymphoma) * Glomerular filtration rate \> 30 mL/min * Not pregnant or nursing * Fertile patients must use effective contraception * No other concurrent uncontrolled medical condition * No active malignant disease, other than non-melanotic skin cancer or carcinoma in situ of the uterine cervix, within the past 10 years * No positive serology for HIV * No medical or psychiatric conditions that compromise the patient's ability to give informed consent PRIOR CONCURRENT THERAPY: * No prior chemotherapy, radiotherapy, or other investigational drug for this indication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall response rate | End of treatment |
Secondary
| Measure | Time frame |
|---|---|
| Toxicity | End of treatment |
| Progression-free survival | Not specified in protocol |
| Overall survival | Not specified in protocol |
Countries
United Kingdom
Outcome results
None listed