Thyroid Function in Late Preterm Infants

Thyroid Function in Late Preterm Infants in Relation to Severity of Illness

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00971555

Enrollment

150

Registered

2009-09-03

Start date

2009-09-30

Completion date

2011-01-31

Last updated

2011-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transient Hypothyroxinemia

Keywords

Transient Hypothyroxinemia, Late Preterm Infants, Total T4, TSH, Illness severity, NICU

Brief summary

Transient hypothyroxinemia (TH) is a condition characterized by low levels of serum thyroxine (T4) and normal levels of thyroid stimulating hormone (TSH). TH in premature infants has been found to be related to severity of illness. T4 levels in very low birth weight infants born prematurely has been found to be inversely correlated to severity of illness. In very low birth weight infants, TH has been associated with poor outcomes. Little is known about thyroid function in late preterm infants. Hypotheses: 1. Ill late preterm infants will have lower total T4 levels than healthy late preterm infants. 2. Total T4 and possibly TSH levels will be inversely correlated with short-term outcomes. 3. Late Preterm infants born by cesarean section will have lower T4 levels compared to those born by vaginal birth.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 7 Days

Healthy volunteers

Yes

Inclusion criteria

* any infant born between 34 0/7 weeks and 36 6/7 weeks gestation born at Christiana Hospital

Exclusion criteria

* outborn infants * infants with major congenital anomalies

Design outcomes

Primary

Measure	Time frame
Correlation of total T4 and TSH with gestational age, birth weight, and mode of delivery.	First week of life

Countries

United States

Outcome results