Remote Ischemic Postconditioning During Percutaneous Coronary Interventions

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00970827

Acronym

RIP-PCI

Enrollment

360

Registered

2009-09-03

Start date

2009-05-31

Completion date

2014-06-30

Last updated

2014-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

Coronary artery disease, PCI, Postconditioning, Elective or urgent PCI

Brief summary

Angioplasty is a commonly performed procedure for treating blockage of the blood vessels in the heart. Although this procedure is usually successful, it is often accompanied by a small degree of damage to the heart (i.e., small heart attack). The purpose of this study is to find out if inflating a blood pressure cuff on the arm or the leg at the time of angioplasty for several minutes has a beneficial effect. Patients will be assigned to one of three treatment groups: inflating blood pressure cuff on the arm, inflating blood pressure cuff on the leg and a control group.

Interventions

PROCEDUREremote ischemic postconditioning

Three 5- minute cycles of blood pressure cuff inflation according to the assigned group. The cuff is inflated to 200 mm Hg (and at least 20 mmHg above the systolic blood pressure) for 5 minutes followed by a 5-minute deflation (reperfusion).

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for PCI

Exclusion criteria

* Acute myocardial infarction * Myocardial infarction or coronary bypass surgery during the last 4 weeks before PCI * Use of Glyburide * Heart failure (NYHA III/IV) * Chronic inflammatory disease * Severe renal impairment * Significant peripheral vascular disease * Unsuitable for use of an embolic protection device for PCI to SVG

Design outcomes

Primary

Measure	Time frame
Myocardial injury after PCI.	24 hours

Secondary

Measure	Time frame
To study the effects of different degrees of remote ischemic postconditioning on myocardial necrosis and inflammation following PCI.	24 hours
Platelet function	24 hours
Cardiac events	One year

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026