Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study

Olfactory Dysfunction of Rhinosinusitis - cAMP/Calcium Signaling Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00970190

Acronym

cAMP

Enrollment

Registered

2009-09-02

Start date

2009-08-31

Completion date

2014-04-30

Last updated

2014-12-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sinusitis

Keywords

sinusitis

Brief summary

The study examines the biochemistry underlying human olfaction in both normal and diseased states. The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal disorders. 2. to correlate preoperative olfactory function with cAMP levels from biopsied olfactory tissue. 3. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using calcium imaging and 4. to determine odorant and pheromone-mediated activation of cultured human olfactory sensory neurons using smell-chip technology.

Detailed description

Subject will be recruited from those scheduled to have endoscopic sinus surgery and similar procedures. This study uses the tissue that would normally be discarded during the surgical process. The tissue is cultured and frozen for purposes of the following testing: odor detection and signal transduction, cyclic adenosine monophosphate and odor detection, the role of cAMP in olfactory dysfunction, and pheromone detection. Only tissue that would normally be discarded during the course of the surgery will be used. The study does not interfere with or change any clinical care.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Subjects will be 18 years old and over and scheduled for one of the following: * endoscopic sinus surgery for chronic sinusitis * endoscopic transnasal approach to the pituitary for pituitary tumor removal * endoscopic inferior turbinectomy or septoplasty for nasal congestion * endoscopic repair of cerebrospinal fluid (CSF) leaks

Exclusion criteria

* Subjects are excluded if they are unable to give informed consent or unable to complete self-administered questionnaires due to English language barrier, cognitive impairment, or severe medical conditions

Countries

United States

Outcome results