Diabetic Neuropathy
Conditions
Keywords
neuropathy, diabetes
Brief summary
The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.
Detailed description
The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.
Interventions
BEHAVIORALExercise
Supervised moderately-intense exercise, including both aerobic and strengthening activities. Sessions are 3-4 days per week for 10 weeks.
Sponsors
Patricia Kluding, PhD
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 40-70 * Type 2 diabetes * Peripheral neuropathy
Exclusion criteria
* Serious cardiac history or other medical problems that would prevent safe participation in exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative sensory testing | 10 weeks |
| Nerve conduction studies | 10 weeks |
| Proprioception | 10 weeks |
| Dermal and epidermal nerve fiber densities | 10 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Clinical assessments of neuropathy, pain, body mass index, muscle strength, and glycemic control (glycosylated hemoglobin or A1C) | 10 weeks |
Countries
United States
Outcome results
None listed