Deficiency, Vitamin D
Conditions
Keywords
Vitamin D, colecalciferol, absorption by Vitamin D
Brief summary
The purpose of this study is to evaluate the absorption of dietary supplement of vitamin D3 (cholecalciferol), through the variation of 25 (OH) D levels, as the fat content of the meal associated with the administration of the supplement.
Detailed description
Clinical randomized controlled double-blind study with healthy subjects to investigate the effect of low and high fat of meal on absorption of vitamin D supplement. Participants were randomly in two groups according to sex and BMI. In the same date, each group of participants received a meal and dietary supplement of vitamin D3 (cholecalciferol) after the first blood sample and a urine sample. Others samples were collected in the seventh and fourteenth day after intake the supplement.
Interventions
DIETARY_SUPPLEMENTcolecalciferol
50.000UI single oral dose
Sponsors
Federal University of Rio Grande do Sul
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Residents of the hospital clinics of Porto Alegre
Exclusion criteria
* Don't drink milk * Obesity * Malnutrition * Liver disease * Kidney disease or diabetes * Use of dietary supplements containing calcium and vitamin D * Medications * Anticonvulsants * Barbiturates, or steroids. * Having performed a journey the last four months to locations near the Earth's equatorial plane, due to sun exposure that may have occurred during this period, or vacations planned during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Level of Vitamin D3 | 14 days |
Countries
Brazil
Outcome results
None listed