Hypertension
Conditions
Keywords
blood pressure, aging, cerebrovascular circulation, hypertension
Brief summary
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.
Interventions
8-12 weeks of anti-hypertensive treatment with 2 weekly titration using registered hypertensive medication
Sponsors
Dutch Heart Foundation
Radboud University Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>= 70 years * Systolic office blood pressure \>= 160 mmHg * Systolic home blood pressure \>= 155 mmHg
Exclusion criteria
* Diabetes Mellitus * Atrial fibrillation * Dementia * Renal failure requiring dialysis * Life expectancy of less than 1 year * Disabling stroke * Contraindication for MRI or anti-hypertensive medication * Systolic blood pressure \> 220 mmHg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood flow | T1, 8-12 weeks of treatment, T2 |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive functioning assessed by neuropsychological testing | T1, 8-12 weeks of treatment, T2-3 |
Countries
Netherlands
Contacts
Primary ContactJaap C Sijbesma, MD
Outcome results
None listed