Hemodynamic Monitoring, Perioperative Complications, Radical Cystectomy
Conditions
Brief summary
The purpose of this study is to determine whether increasing cardiac output by a combination of intravenous fluids and inotropic drugs can reduce mortality and morbidity in radical cystectomy operations.
Interventions
OTHERIncreasing oxygen delivery .
The target is increasing oxygen delivery above 600ml/min/mr2 by either bolus of iv colloid or a continuous infusion of dopamine, dobutamine or noradrenaline. The fluids and drug administration will be directed and monitored by the lidco system and transesophageal echocardiography.
Sponsors
Hadassah Medical Organization
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults (\>18yo) scheduled for elective radical cystectomy and ileal conduit formation
Exclusion criteria
* Creatinine level above 200 mcg/dl * single functioning kidney * s/p kidney transplant * heart rhythm other than sinus * known allergy to lithium chloride * chronic lithium therapy * weight below 40 kg * mental or language problems that precludes obtaining informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality | Hospital stay |
Secondary
| Measure | Time frame |
|---|---|
| Morbidity | Hospital stay |
Countries
Israel
Contacts
Primary ContactYuval Meroz, MD
Outcome results
None listed