Adhesions of Nasal Cavity, Nasal Adhesions, Nasal Synechiae, Tissue Adhesions
Conditions
Keywords
Nasal adhesions, Nasal synechiae, Mitomycin, Mitomycin c, Teflon, Splints, Septal splints
Brief summary
This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
Detailed description
Nasal synechiae is an important cause for the failure of many a nasal surgery. Septal splints have been widely used for the treatment of nasal synechiae, but are associated significant morbidity until removal. To the best of our knowledge there are no studies in literature comparing Mitomycin C with septal splints as an atraumatic alternative in the treatment of nasal synechiae. This is a preliminary study taken up to evaluate the therapeutic efficacy of Mitomycin C in the treatment of nasal synechiae.
Interventions
DRUGMitomycin C
Cotton wick soaked with 1mg/ml of mitomycin c placed for 2 minutes between the raw surfaces after synechiolysis with surgical blade no.15
DEVICETeflon nasal septal splint
Teflon internal nasal septal splint placed between the raw surfaces and secured at the anterior end of septum with catgut 3-0 sutures, following synechiolysis with surgical blade no.15. Splint removed at the end of one week
Sponsors
Karnataka Institute of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with nasal mucosal synechiae due to surgical or non-surgical trauma
Exclusion criteria
* Patients with nasal vestibular stenosis * Patients with nasal synechiae due to diseases like Hansen's disease, Syphilis, Rhinoscleroma, Atrophic Rhinitis etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence or absence of synechiae | 1 week, 1 month, 2 months |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms and complications | 1 week, 1 month, 2 months |
Countries
India
Outcome results
None listed