Predictors of the Metabolic Effect of Sleep Loss

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00965783

Acronym

SDBO

Enrollment

Registered

2009-08-26

Start date

2007-06-30

Completion date

2009-12-31

Last updated

2013-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Apnea, Obstructive Sleep Apnea (OSA), Obesity

Keywords

Sleep, Apnea, OSA, obese, middle-aged

Brief summary

To test whether baseline levels of slow wave activity (SWA) during sleep are lower in obese adults, and even lower in persons with sleep disordered breathing (SDB) compared to lean adults. To compare levels of SWA in individuals in relation to their sleep time, blood pressure, heart rate, and markers of glucose metabolism.

Interventions

OTHERRestriction

Time in bed for each subject is restricted by two hours per night for 4 nights

OTHERExtension

Bedtime is extended by 2 hours per night for 4 nights

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy, * normal sleepers, * lean, overweight, * obese, * pre menopausal

Exclusion criteria

* no shift workers or night-shift workers, * no mental health disorders, * no acute or chronic health conditions (stable, well controlled hypertension are accepted), * no hormonal treatments, * no substances that may interfere with sleep, * problems with sleep

Design outcomes

Primary

Measure	Time frame
Correlation between SWA, sleep duration,sleep architecture, and biomarkers of the metabolic syndrome in lean, obese with and without obstructive sleep apnea.	study completion

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026