Thymoma
Conditions
Brief summary
This is a retrospective analysis of biological characteristics of thymoma and thymic carcinoma patients.
Detailed description
The aim of the present study is to investigated the genetic alterations in tumor samples of a series of all WHO-defined subtypes of thymoma patients using high resolution microarray- comparative genomic hybridization (CGH) followed by hierarchical cluster analyses of the data to identify specific patterns of genetic aberrations and genes associated with each subtype. Moreover, tumor samples will be also investigated for some specific potential therapy targets by immunoistichemistry, mutation analysis, and fluorescence in situ hybridization (FISH) analysis. All these biological data will be correlated with clinical patients characteristics and survival data.
Interventions
None listed
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Availability of tumor tissue and patients with thymoma and thymic carcinoma
Exclusion criteria
* NON Availability of tumor tissue and patients with thymoma and thymic carcinoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective: to evaluate the presence of genetic alterations and specific potential therapy targets. | one year |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective: to correlate the biological characteristics with clinical characteristics and survival data of patients. | one year |
Countries
Italy
Outcome results
None listed