Influenza
Conditions
Keywords
severe, acute, influenza, consortium, swine, flu, influenza A, H1N1, hospital, admission
Brief summary
The ultimate goal of this collaborative, intensive study is to discover new and effective treatments and to develop better vaccines that can be used in future outbreaks of Influenza A. By integrating the information that we will gather, we will create a unique overview of how influenza causes illness and what might be done to improve patient management.
Detailed description
Influenza A is one of the best studied viruses, but continues to have a very large impact on human and animal health. In addition to causing outbreaks of winter flu, it sometimes mutates to create a new virus that spreads quickly around the world. It is puzzling that the same virus appears to cause minor or absent symptoms in some people while killing others. Much remains to be understood. The investigators have assembled an unprecedented group of internationally renowned scientists from England and Scotland who will together focus on studying a few hundred people hospitalised during the current swine flu pandemic. Such a large scale project has never before been attempted, but we are now poised to work together and integrate the many recent advances in biomedical science that relate to understanding how influenza causes disease.
Interventions
None listed
Sponsors
Wellcome Trust
Medical Research Council
Imperial College London
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Any patient admitted to hospital with suspected or confirmed influenza infection
Exclusion criteria
* Patients who do not give their consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways. | 15 months | Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages. |
Countries
United Kingdom
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Influenza Diagnosis Patients admitted to hospital with a suspected or confirmed influenza diagnosis on admission | 131 |
| Total | 131 |
Baseline characteristics
| Characteristic | Influenza Diagnosis |
|---|---|
| Age, Continuous | 42 years |
| Region of Enrollment United Kingdom | 131 participants |
| Sex: Female, Male Female | 63 Participants |
| Sex: Female, Male Male | 68 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | 0 / 131 |
| other Total, other adverse events | 0 / 131 |
| serious Total, serious adverse events | 0 / 131 |
Outcome results
Primary
Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways.
Detailed clinical phenotype. Clinicopathological correlation will then be sought between the clinical phenotype and pathological parameters measured as per work packages.
Time frame: 15 months
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Influenza Diagnosis | Number of Patients With Clinical Phenotype Presenting Also a Sequential Activation of Immune/Infammatory Pathways. | 131 Participants |