Acute Lung Injury, Mechanical Ventilation
Conditions
Keywords
NAVA, Acute Lung Injury, Pressure Support Ventilation, Intubation, Tracheostomy, Mechanical ventilation
Brief summary
Evaluation of a new ventilatory mode Neurally Adjusted Ventilatory Assist "NAVA" in patients who recover spontaneous breathing after acute lung injury.
Detailed description
Physiological evaluation of two modes of mechanical ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation, at different levels of ventilator assistance. Evaluation in term of physiological parameters: Tidal volume, Respiratory rate, Inspiratory effort, PaCO2, evaluation of subject-ventilator synchrony. Evaluation of physiological response to varying levels of ventilator assistance.
Interventions
DEVICEPSV - pressure suppot ventilation
Gold standard partial ventilator support: Pressure Support Ventilation performed with Servo-i® ventilator (MAQUET,Critical Care, Sweden). Different levels of pressure support ventilator assistance are tested.
DEVICENAVA - Neurally Adjusted Ventilatory Assist
Partial ventilator support with new partial ventilation mode (NAVA) performed with Servo-i® ventilator (Maquet,Critical Care, Sweden). Different levels of neurally adjusted ventilatory assist are tested. Positive pressure, delivered by the machine, is driven using inspiratory flow trigger.
DEVICENAVA - EMG
Partial ventilator support with new partial ventilation mode (NAVA) performed with Servo-i® ventilator (Maquet,Critical Care, Sweden). Different levels of neurally adjusted ventilatory assist are tested. The machine applies positive pressure throughout inspiration in proportion to the electrical activity of the diaphragm (Eadi). Eadi was obtained trhough a naso-gastric tube with multiple array of electrodes placed at its distal end (Eadi catheter® , Maquet Critical Care, Sweden).
Sponsors
University Hospital, Caen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \> 18 years * Hospitalized in intensive care unit * Acute Lung Injury * Intubated or tracheotomized and mechanically ventilated
Exclusion criteria
* Hemodynamic instability * Absence of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of physiologic response to varying levels of pressure support and Neurally Adjusted Ventilatory Assist (NAVA) | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Subject-ventilator synchrony | 24 hours |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORNicolas TERZI, MD
University Hospital, Caen
Outcome results
None listed