Alcoholism
Conditions
Brief summary
This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by: 1. Examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns. 2. Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews. 3. Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.
Interventions
DRUGEthanol
Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol
DRUGPlacebo
Beverage containing 0.0 g/kg alcohol to act as placebo
DRUGDiphenhydramine
Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl)
DRUGCaffeine
Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake
Sponsors
University of Chicago
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 21-65 * Weigh between 110-210 lbs * Drink alcohol at least once weekly with weekly "binge" drinking episodes * Available to complete in-person screening and 2, 4 hour experimental sessions at the University of Chicago * Available by phone, mail, or Internet for follow-up interviews for at least 2 years following sessions
Exclusion criteria
* Current or past major medical or psychiatric disorders including alcohol and substance dependence
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers | Measured during 5 timepoints at each experimental session: 1) Pre-drink baseline, 2) +30 minutes, 3) +60 minutes, 4) +120 minutes, and 5) +180 minutes following the initiation of beverage consumption |
Secondary
| Measure | Time frame |
|---|---|
| Substance Use Behavior Reported During Follow-Up Interviews | Measured at 3, 6, 9, 12, 15, 18, 21, 24, 36, 48, and 60 months following the final experimental session |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAndrea C King, PhD
University of Chicago
Outcome results
None listed