Diabetes, Prediabetic State
Conditions
Keywords
vitamin K, beta cell, glucose metabolism, insulin resistance
Brief summary
The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response.
Detailed description
Recently, many studies have reported that vitamin K metabolism is related to glucose metabolism. The suggested mechanisms connecting vitamin K metabolism and glucose metabolism, are inflammation responses and osteocalcin effect on glucose metabolism. Most of the studies have investigated fasting glucose and insulin sensitive index, few have assessed glucose-intake-stimulated responses in regard to vitamin K supplementation. The purpose of this study is to test whether vitamin K supplementation has an effect on glucose metabolism in terms of acute beta cell response using intravenous glucose tolerance test.
Interventions
DRUGMenatetrenone
Menatetrenone 30 mg, 3 times a day for 4 weeks
DRUGPlacebo
Placebo
Sponsors
Seoul National University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteer older than 20 years
Exclusion criteria
* Subjects with (a history of) diabetes * Subjects receiving medication related to diabetes or obesity * Subjects receiving warfarin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AIRg (acute insulin response to glucose) using FSIGT (frequently sampled intravenous glucose tolerance test) | 4 weeks later |
Secondary
| Measure | Time frame |
|---|---|
| beta-cell function (FSIGT) | 4 weeks later |
| disposition index (FSIGT) | 4 weeks later |
| insulin sensitivity (FSIGT) | 4 weeks later |
Countries
South Korea
Outcome results
None listed