Atherosclerosis
Conditions
Keywords
coronary calcium scoring, breast cancer patients, radiation treatment
Brief summary
The purpose of this study is to compare plaque burden in the coronary and carotid arteries 5 years after adjuvant radiotherapy in women with right sided breast cancer vs left sided breast cancer.
Detailed description
This study reviews case series of patients with a history of breast cancer treated with radiotherapy for at least five years. The study measures atherosclerosis by using coronary and carotid artery calcium scoring.
Interventions
None listed
Sponsors
Winthrop University Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* women dx with ductal carcinoma in situ or breast cancer, stage 0 to stage IIIc, who received conservative surgery and radiotherapy at least 5 years ago * less than or equal to age 60
Exclusion criteria
* hx of coronary disease prior to tx of ductal carcinoma in situ or breast cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants Analyzed for Coronary Calcium Burden by AGS | Year 5 Post-Initiation of Radiotherapy | Number of participants who received a coronary calcium scan. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Coronary Artery Evaluation Left Side Breast Cancer 9 left sided breast cancer | 9 |
| Coronary Artery Evaluation Right Side Breast Cancer 11 right sided breast cancer | 11 |
| Total | 20 |
Baseline characteristics
| Characteristic | Coronary Artery Evaluation Left Side Breast Cancer | Coronary Artery Evaluation Right Side Breast Cancer | Total |
|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 9 Participants | 11 Participants | 20 Participants |
| Sex: Female, Male Female | 9 Participants | 11 Participants | 20 Participants |
| Sex: Female, Male Male | 0 Participants | 0 Participants | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 20 |
| serious Total, serious adverse events | 0 / 20 |
Outcome results
Primary
Number of Participants Analyzed for Coronary Calcium Burden by AGS
Number of participants who received a coronary calcium scan.
Time frame: Year 5 Post-Initiation of Radiotherapy
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Coronary Artery Evaluation Left Side Breast Cancer | Number of Participants Analyzed for Coronary Calcium Burden by AGS | 9 Participants |
| Coronary Artery Evaluation Right Side Breast Cancer | Number of Participants Analyzed for Coronary Calcium Burden by AGS | 11 Participants |