Biomarkers of the Response to Osteopathic Manipulation

Identification of Biomarkers for Investigating Osteopathic Manipulative Treatment

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00958646

Enrollment

Registered

2009-08-13

Start date

2009-08-31

Completion date

2010-12-31

Last updated

2011-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

OMT, biomarker, Manipulation, osteopathic

Brief summary

The purpose of this study is to identify non-invasive biomarkers of the physiologic response to Osteopathic Manipulative Treatment (OMT).

Interventions

OTHEROsteopathic Manipulation

Standardized rib raising protocol

OTHERPlacebo

Light touch control procedure

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

21 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adults between the ages of 21 and 60

Exclusion criteria

* Eating or drinking anything but water or chewing gum within an hour of the appointment * Rib fracture * History of unstable cardiac arrhythmia or symptoms related to the chest cavity (difficulty breathing, chest pain) * Symptoms suggestive of bowel obstruction (abdominal bloating with pain, nausea and vomiting, diarrhea) * Pregnancy * History of Sjogren's Syndrome

Design outcomes

Primary

Measure	Time frame
Salivary amylase levels	baseline, 10 minutes post procedure

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026