Healthy
Conditions
Keywords
satiety, fiber, food intake, gut hormones, visual analog scales, microflora
Brief summary
Research suggests dietary fiber may play a role in weight management, and fiber consumption is inversely associated with body weight, body fat, and BMI in cross-sectional studies. These effects may be mediated by increased satiety, reduced food intake, or changes in blood levels of glucose, insulin, and gut hormones. The purpose of this study is to determine the satiety, glycemic, hormonal, and gastrointestinal responses of novel fiber supplements.
Interventions
DIETARY_SUPPLEMENTPlacebo
Low fiber muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
DIETARY_SUPPLEMENTResistant Starch
25 g resistant starch, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
DIETARY_SUPPLEMENTResistant starch + soluble fiber
25 g fiber as resistant starch and a soluble fiber, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
DIETARY_SUPPLEMENTFiber made from corn starch
25 g fiber made from corn starch, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
DIETARY_SUPPLEMENTFiber made from corn starch + soluble fiber
25 g fiber as a fiber made from corn starch and a soluble fiber, administered in a muffin, hot cereal and beverage (acute phase) or fiber bars and beverage (chronic phase)
Sponsors
Tate and Lyle Ingredients France
University of Minnesota
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy men and women * age 18-60 years * non-smoking * not taking medication * non-dieting (weight stable in prior 3 months) * BMI 18-27 * English literacy * ability to give blood
Exclusion criteria
* do not regularly consume breakfast * food allergies to ingredients found in study products * dislike for muffins, fiber bars, or hot cereal * BMI \<18 or \>27 * diagnosed cardiovascular, renal, or hepatic disease * diabetes mellitus (fasting blood sugar \>126 mg/dl) * cancer in previous 5 years (except basal cell carcinoma of the skin) * any gastrointestinal disease or condition * recent bacterial infection (\< 3 months) * recent or concurrent participation in an intervention research study * history of drug or alcohol abuse in prior 6 months * use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication * restrained eaters * vegetarians * people who eat more than approximately 15 grams of fiber per day * women who are pregnant or lactating * women with irregular menstrual cycles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Satiety | 0, 15, 30, 45, 60, 90, 120, 180, 215 minutes postprandially |
Secondary
| Measure | Time frame |
|---|---|
| ad libitum food intake | 180 minutes postprandially and over 24 hours |
| Ghrelin, polypeptide YY (PYY), and glucagon-like peptide-1 (GLP-1) response | 0, 30, 60 minutes postprandially |
| Gastrointestinal tolerance and fecal chemistry | following 7 days of treatment |
| Glucose/Insulin Response | 0, 15, 30, 45, 60, 90, 120, 180 minutes postprandially |
Countries
United States
Outcome results
None listed