Healthy Infants
Conditions
Keywords
Healthy Infants, Satiation, Satiety, Intake Regulation, Infant Feeding, Infant Formula Feeding
Brief summary
There is a paucity of information on whether and how the composition of formulas fed to infants influences their short-term feeding behaviors during the first few months of life. The purpose of this study is to investigate whether the composition of infant formula affects infants' feeding behaviors, in particular, how much formula is consumed within a given feed (i.e., measure of satiation) and how much time elapses after the feed until the infant exhibits signs of hunger (i.e., measure of satiety). The investigators will also examine the relationship between the composition of infant formula consumed and infant temperature, activity, sleep, and mothers' perceptions of infants' intake and regulatory behaviors.
Detailed description
This is a within-subject, 3-day study. Each mother-infant dyad will visit the Monell Center three times, for 5 hours each time. The protocol during the three visits will be identical. Upon arrival, the infant will be changed into a light-weight cotton body suit. Infants and mothers will be weighed and measured for height. An activity sensor will be placed on the infant and temperature sensors will be placed on both the infant and the mother. When the infant signals hunger, he/she will be fed one of three formulas in randomized order: 1. cow milk based-formula (Enfamil) 2. protein hydrolysate formula (Nutramigen) 3. cow milk-based formula with glutamate level similar to Nutramigen (Enfamilg) Intake will be monitored and all feeds will be videotaped. In between feedings, infants will rest or sleep on their backs in a crib and mothers will fill out questionnaires.
Interventions
None listed
Sponsors
Ajinomoto USA, INC.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Monell Chemical Senses Center
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
1 Months to 4 Months
Healthy volunteers
Yes
Inclusion criteria
* Healthy, term infants of any racial background * Infants may be of either sex * Infants must be between 1 and 4 months of age * Infants must be exclusively feeding a cow's milk-based formula * Mothers must be over 18 years of age
Exclusion criteria
* Infants who were preterm * Infants who have medical conditions that interfere with feeding or eating * No major complications during pregnancy or at birth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Satiation: volume of formula consumed within a feed | 5-hour period |
| Satiety: the duration between feedings | 5-hour period |
Secondary
| Measure | Time frame |
|---|---|
| Infant temperature change | 5-hour period |
| Infant sleep and activity patterns | 5-hour period |
| Maternal perceptions | 5-hour period |
Countries
United States
Outcome results
None listed