Androgen Deprivation Therapy, Osteoporosis, Prostate Cancer
Conditions
Keywords
Prostate cancer, androgen deprivation therapy, osteoporosis
Brief summary
The purpose of this study is * to determine the rate of osteoporosis among patients with advanced prostate cancer. * to propose an algorithm for early detection of patients with advanced prostate cancer who are at risk of developing osteoporosis.
Detailed description
Patients with advanced prostate cancer are included at the initiating of androgen deprivation therapy. The patients are followed for 2 years after inclusion with blood sampling, DXA-scan, questionnaire, bone scintigraphy.
Interventions
PROCEDUREblood sampling, DXA-scan, bone scintigraphy
Blood sampling 5 times DXA-scan 5 times Bone scintigraphy 3 times
Sponsors
Zealand University Hospital
Odense University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
MALE
Healthy volunteers
No
Inclusion criteria
* Prostate cancer * Initiation of androgen deprivation therapy * Oral and written informed consent
Exclusion criteria
* They withdraw their consent * Treatment for osteoporosis within the last year * Other malignancy * Other bone disease, bedbound, use of steroid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Osteoporosis, either T-score < -2,5 or osteoporosis fracture | 2½ years |
Countries
Denmark
Contacts
Primary ContactMads H Poulsen, MD
Backup ContactSteen Walter, MD, DMSci, Professor
Outcome results
None listed