Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function

Effects of Intermittent Hypoxia and/or Cigarette Smoking on Endothelial Injury in Vivo - Relevance to Obstructive Sleep Apnea

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00957463

Enrollment

150

Registered

2009-08-12

Start date

2008-06-30

Completion date

Unknown

Last updated

2014-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea, Smoking

Keywords

endothelial function

Brief summary

The hypothesis of this study is that either obstructive sleep apnea (OSA) or cigarette smoking (CS) exposure would produce oxidative stress and inflammation leading to endothelial injury, and the combined exposure would be additive or synergistic.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* No acute illness * No hospitalization in past 4 weeks * Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness

Exclusion criteria

* Mentally incapacitated

Design outcomes

Primary

Measure	Time frame
reactive hyperemia induced peripheral arterial tone (RH-RAT) index	baseline

Secondary

Measure	Time frame
circulatory metabolic and vascular inflammatory biomarkers	baseline

Countries

Hong Kong

Outcome results