Analgetic Effect of Preoperative Pregabalin in Patients Undergoing Nephrectomy

Effect of Preoperative Pregabalin Administration on the Postoperative Opioid Consumption in Patients Undergoing Nephrectomy

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00957177

Acronym

PregabaNeph

Enrollment

Registered

2009-08-12

Start date

2009-04-30

Completion date

2010-12-31

Last updated

2011-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Brief summary

Pregabalin 300mg or placebo are administered 1 hour preoperatively in patients undergoing elective nephrectomy. Postoperatively, patients receive a patient controlled analgesia device for self delivering opioids. Morphine consumption in the first 48 hours is documented. Hyperalgesia is measured by von-Frey-Filaments.

Interventions

DRUGPregabalin

300mg pregabalin orally 1 hour before operation

DRUGPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* patients undergoing elective nephrectomy

Exclusion criteria

* contraindication against pregabalin * creatinine \> 2.0 mg/dl * GGT \>165, AST \>105, ALT \>135 * peptic Ulcus * haemorrhagic diathesis * angina pectoris, myocardial infarction * stroke * bronchial asthma * opioid abuse

Design outcomes

Primary

Measure	Time frame
postoperative opioid consumption	48 hours

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026