Cancer Pain Single Nucleotide Polymorphisms (SNPs)

Storage and Analysis of Patient Blood-samples for Cancer Pain Research

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00956878

Enrollment

243

Registered

2009-08-11

Start date

2008-09-30

Completion date

2012-12-31

Last updated

2014-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer, Pain

Keywords

Cancer, Pain, SNP

Brief summary

Cancer pain is common in advanced cancer patients. Opioids are the mainstay of treatment in cancer pain. Responsiveness to and tolerability of opioids is, amongst others, determined by small variations in human DNA. Using blood samples from clinically well-defined cancer pain patients, the investigators are going to analyze single nucleotide polymorphisms (SNPs) in genes that are known to be involved in responsiveness to opioids and sensitivity to pain.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Cancer pain patients

Exclusion criteria

* Patients not able to provide informed consent

Design outcomes

Primary

Measure	Time frame	Description
correlation between pain SNPs and equianalgesic opioid requirement	timepoint at blood sample	candidate SNP analysis

Countries

Netherlands

Outcome results