Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes

Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes: A Novel Intervention for a High Risk Population

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00956735

Acronym

Pistachio

Enrollment

Registered

2009-08-11

Start date

2009-08-31

Completion date

2013-03-31

Last updated

2013-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease, Type 2 Diabetes

Keywords

Cardiovascular Disease, Type II Diabetes, Nutrition, Pistachios, Cardiovascular disease risk factors in adults with Type II diabetes

Brief summary

This study is investigating the effects of three different diets, including a diet with pistachios, on cardiovascular disease risk markers in people with type 2 diabetes.

Detailed description

The study will last 12-16 weeks and requires 10-13 visits to the General Clinical Research Center on the University Park campus. All food and snacks will be provided for 10 weeks. At the end of each of three diet periods, participants will undergo a test of endothelial function, an oral glucose tolerance test, and a cardiovascular stress reactivity test.

Interventions

OTHERPistachio

3.0 oz (2 servings) of roasted and salted or unsalted pistachios

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Healthy, nonsmoking adults, aged 30-75 years (women must be post-menopausal) * Diagnosed with Type 2 diabetes

Exclusion criteria

* Insulin, more than one blood pressure lowering medication, daily aspirin, NSAID therapy, oral steroids within the last 6 weeks, oral contraceptives, and hormone replacement therapy * Chronic disease such as cardiovascular disease or any complications of diabetes (retinopathy, neuropathy, etc). * Allergies or aversions to pistachios * Unwillingness to consume all foods provided and no other meals or snacks for the 10 weeks of diet intervention

Design outcomes

Primary

Measure	Time frame
Cardiovascular responses to stress	End of each diet period
Insulin sensitivity and resistance	End of each diet period
Lipids and lipoproteins	End of each diet period

Secondary

Measure	Time frame
Vascular endothelial function	End of each diet period
Mood and perceived stress	End of each diet period

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026