Obesity
Conditions
Brief summary
The investigators will test the hypothesis that a LOW CARB hypocaloric diet will reduce body weight over six months more than a LOW FAT hypocaloric diet. In addition to body weight, the investigators will measure cardiovascular and metabolic variables and will take blood samples in order to determine whether certain metabolites may predict the diet success.
Interventions
BEHAVIORALdietary intervention
dietary counseling, group teaching
Sponsors
Hannover Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Body Mass Index \> 27 kg/m2 * No chronic medication (except oral contraceptives and L-Thyroxine) or possibility to stop medication for study duration * Able to give written informed consent
Exclusion criteria
* Pregnancy and nursing * Severe cardiovascular, liver, kidney, hepatic or orthopedic disease that need treatment * Metabolic or endocrine disease that need treatment * Hypertension blood pressure \> 160/95 mmHg or need of \> 2 drugs * Previous stroke or cerebral ischemia * Significant neurologic or psychiatric disease * Any kind of eating disorder * Bariatric surgery in the past * Drug or alcohol abuse * Any cancer in the past * Acute and chronic infections * Metallic implants (e.g. pace makers) or conditions that do not allow MRI scans * Body weight \> 130 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight reduction | Month 6 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weight maintenance | Month 12 - 36 | follow up assesement after 6 months diet |
| Reduction of visceral adipose tissue mass | Month 6 | — |
| Reduction of left ventricular mass | Month 6 | — |
| Influence on energy expenditure and fat oxidation rates | Month 6 | — |
Countries
Germany
Outcome results
None listed