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Comparison of Physical Activity Regimens as Treatments for Obstructive Sleep Apnea

Exercise: A Novel Treatment for Obstructive Sleep Apnea

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00956423
Enrollment
43
Registered
2009-08-11
Start date
2009-08-31
Completion date
2011-10-31
Last updated
2011-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea

Keywords

obstructive sleep apnea, exercise training, aerobic exercise, resistance exercise

Brief summary

The purpose of this study is to compare the efficacy of two different physical activity regimens as complementary or alternative treatment options for the treatment of obstructive sleep apnea. A secondary purpose of the study is to examine the effects of these activity regimens on various health consequences of obstructive sleep apnea, including blood pressure, systemic inflammation, and daytime functioning.

Interventions

BEHAVIORALmoderate-intensity aerobic and resistance training

Individuals will complete four days of aerobic exercise of moderate intensity (60% of maximal VO2, approximated from heart rate). Duration of aerobic activity will gradually increase from weeks 1 through 4 until 180 min of aerobic exercise at the prescribed intensity is performed each week. Following aerobic exercise on two days per week, moderate-intensity resistance training will be performed using eight different resistance machines. One set of 8-12 repetitions will be performed during weeks 1-4; from week 5-on, 2 sets of 8-12 repetitions will be performed.

BEHAVIORALlow-intensity stretching

Individuals will perform supervised whole-body flexibility exercises on two days per week. Two sets of each exercise will be performed, with the duration of each stretch gradually increasing from 15 sec to 30 sec. A total of 15-20 stretches, focusing on whole-body flexibility, will be performed.

Sponsors

University of South Carolina
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* moderate-intensity obstructive sleep apnea (AHI \>= 15) * sedentary status

Exclusion criteria

* current treatment for obstructive sleep apnea (CPAP, oral devices, etc.) * significant cardiovascular, pulmonary, or metabolic disease * uncontrolled hypertension * inability to exercise (e.g., musculoskeletal, neuromuscular, orthopedic problems)

Design outcomes

Primary

MeasureTime frame
Laboratory polysomnographic assessment of apnea-hypopnea indexpre- and post-intervention (12 weeks later)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 27, 2026