Polycystic Ovary Syndrome
Conditions
Keywords
Polycystic ovary syndrome, clomiphene resistance, letrozole, Laparoscopic ovarian diathermy
Brief summary
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of laparoscopic ovarian diathermy (LOD) in infertile women with Polycystic ovary syndrome(PCOS)not responding to treatment with Clomiphene alone.
Detailed description
In the letrozole group, withdrawal bleeding was achieved using 10 mg of dydrogesterone tablets for 10 days before stimulation, then 2.5 mg of letrozole oral tablets (Femara; Novartis Pharma Services, Switzerland) daily from day 3 of the menses for 5 days up to six cycles. All patients in the control group underwent laparoscopic ovarian diathermy, then followed up for 6 months.
Interventions
DRUGLetrozole
2.5 mg letrozole oral tablets daily from day 3 of the menses for 5 days up to 6 cycles
PROCEDURELaparoscopic ovarian diathermy (LOD)
Three-puncture technique. Each ovary was cauterized at four points, each for 4 seconds at 40 W for a depth of 4 mm with a mixed current, using an monopolar electrosurgical needle.
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* CC resistant PCOS
Exclusion criteria
* Congenital adrenal hyperplasia * Cushing syndrome * Androgen secreting tumors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| occurrence of ovulation and midcycle endometrial thickness (mm). | — |
Secondary
| Measure | Time frame |
|---|---|
| occurrence of pregnancy, miscarriage, multiple pregnancy and live birth rates. | — |
Countries
Egypt
Outcome results
None listed