Pneumonia
Conditions
Brief summary
Investigators in the Division of Infectious Diseases and the Division of Hospital Medicine of The George Washington University Medical Center are carrying out a study to determine if hospitalized patients receiving the polyvalent pneumococcal vaccine during an acute illness develop an adequate antibody response. The study group will consist of individuals diagnosed with pneumonia and admitted to the Medicine ward under the Pneumonia Core Measure Protocol, which assigns appropriate patients for vaccination based on the current guidelines from the Advisory Committee on Immunization Practices (ACIP).
Interventions
OTHERPre and post vaccination titers
Titers will be obtained pre vaccination and 4 weeks post vaccination
Sponsors
George Washington University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Males or female patients ages 18 or older * Diagnosis of pneumonia requiring hospitalization * Admission to the Medicine Ward under the Pneumonia Core Measure protocol * Eligible to receive standard of care pneumococcal vaccine by the treating physician * Able to receive an injection * Able to provide informed consent
Exclusion criteria
* Preexisting history of immunosuppression, to include any of the following: HIV/AIDS, Chronic corticosteroid use, Malignancy requiring myeloablative chemotherapy, Hematologic malignancy, History of solid organ or stem cell transplant * Pregnancy * Receipt of pneumococcal vaccine within the last 5 years * Prior history of hypersensitivity reaction to the vaccine * Unable to return for follow-up testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A change in the pre- and post-vaccination pneumococcal serotype-specific IgG concentration from baseline will be considered protective based on the laboratory reference range. | 5 weeks |
Countries
United States
Outcome results
None listed