Periodontal Treatment Associated With Hyperbaric Oxygen Therapy

Periodontal Therapy in Severe Cases of Periodontitis: Preliminary Findings of Non-surgical Instrumentation With or Without Hyperbaric Oxygen Therapy (HBOT)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00955643

Enrollment

Registered

2009-08-10

Start date

2002-03-31

Completion date

2003-04-30

Last updated

2009-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Disease

Keywords

periodontitis, hyperbaric oxygen therapy

Brief summary

Evaluation of the clinical effect of hyperbaric oxygen therapy (HBOT) adjunctively to scaling and root planing (SRP) in the treatment of severe case of chronic periodontitis.

Detailed description

Materials and Methods: In 20 patients diagnosed with severe generalized chronic periodontitis (pockets\>7mm) with bleeding on probing, SRP was rendered in all pockets. Additionally, five consecutive hyperbaric sessions were administered in 10 patients after random allocation (SRP+HBOT). Clinical parameters were assessed at baseline up to 6 months: plaque index (PI), bleeding on probing, probing depth, clinical attachment level and BANA test. Results: SRP+HBOT resulted in greater probing reduction and attachment gain than SRP alone 3 months after treatment (p\<0.001). The BANA test was negative after 1 week only for sites in the SRP+HBOT group (p\<0.05). However SRP+HBOT failed to show a significant difference from SRP group after 3 months were all BANA sites became negative (p\>0.05). Conclusion: These preliminary data suggest that hyperbaric oxygen therapy had a short-term beneficial effect on pocket reduction and bacterial elimination, and may be considered a potential therapy option to improve the clinical outcomes of scaling in severe cases of chronic periodontitis.

Interventions

OTHERoxygen

OTHERother

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* This preliminary (pilot) study was designed with twenty subjects (12 men, 8 women, mean age 37.3 years) selected from a pool of 360 patients referred to the Periodontal Clinic of the School of Dentistry at Bahian Science Foundation (FBDC, Bahia, Brazil). * The patients had an initial diagnosis of severe generalized chronic periodontitis (AAP 1999).

Exclusion criteria

* Patients were excluded according to the following criteria: * smoking * pregnancy or lactation * antibiotics or periodontal treatment within the last 6 months * a diagnosis of aggressive periodontitis * trauma from occlusion or endodontic lesions * According to an accurate clinical examination performed by a hyperbaric medical doctor (MD), the HBOT contra-indications (Iazzeti & Mantovani 1998) served as

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026